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KMID : 1103720190800040717
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Journal of the Korean Society of Radiology
2019 Volume.80 No. 4 p.717 ~ p.727
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Correlation of the Strain Elastography-Derived Elasticity Scores with Prognostic Histologic Features, Immunohistochemical Markers, and Molecular Subtypes of Invasive Ductal Carcinoma
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Cho Dong-Ho
Park Chang-Suk
Kim Sung-Hun
Kim Hyun-Suk
Kim Ki-Jun
Lee Jung-Whee
Shin Yu-Ri
Jun Seung-Ah
Oh Se-Jeong
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Abstract
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Purpose: To investigate the correlation of the strain elasticity of breast cancer with histologic features, immunohistochemical markers and molecular subtypes that are known to be factors related to prognosis.
Materials and Methods: B-mode ultrasound and strain elastography were performed in 123 patients (mean age, 53.4; range, 28?82) with invasive ductal carcinoma (IDC) (mean size, 1.54 cm; range, 0.4?7.0 cm). Histologic grade, lymph node (LN) status, lymphovascular invasion, immunohistochemical biomarkers [estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2), CK5/6, epidermal growth factor receptor, and Ki-67] and molecular subtypes were determined from surgical pathology reports. The relationships between these factors and elasticity scores were evaluated.
Results: LN involvement was associated with a higher elasticity score which was statistically significant (p = 0.042). The tumor size, lymphovascular invasion, histologic grades, immunohistochemical markers and molecular subtypes had no significant correlation with the elasticity score (p > 0.05 for all). However, the IDCs with larger size and a positive lymphovascular invasion tended to have higher elasticity scores. Furthermore, higher histologic grade cancers and the HER2 overexpression-type tended to have lower elasticity scores.
Conclusion: The elasticity score of IDC had a significant correlation with LN involvement but no statistically significant correlation with the histologic features, immunohistochemical markers or molecular subtypes.
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KEYWORD
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Breast Neoplasms, Ultrasound, Elastography, Immunohistochemistry, Prognosis
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